Research and Development Pillar
- Al Rihani SB, Deodhar M, Darakjian LI, et al. Quantifying anticholinergic burden and sedative load in older adults with polypharmacy: A systematic review of risk scales and models [published online ahead of print, 2021 Nov 9]. Drugs Aging. 2021;10.1007/s40266-021-00895-x.
- Axon DR, Johnson M, Abeln B, Forbes S, Anderson EJ, Taylor AM, Aseret-Manygoats T, Warholak T, Hall-Lipsy E. An academic-community collaboration to deliver medication therapy management (MTM) services to patients living in rural counties of a southwestern state in the United States. J Pharm Pract. 2021 Mar 24:8971900211000219.
- Badowski M, Bente J, Davis E, Isaacs D, Lewis L, Martello J, Pitlick M, Silva Almodovar A, et al. Telehealth and technological applications in patient-centered care: Implications for pharmacy learners and clinical pharmacists. J Am Coll Clin Pharm. July 2021. Epub ahead of print. DOI: 10.1002/jac5.1490.
- Bankes D, Pizzolato K, Stein A, Finnel S, Awadalla M, Johnson J, Turgeon J. Medication-related problems identified by pharmacists in an Enhanced Medication Therapy Management model. Am J Manag Care. 2021;27(suppl 16):S292-S299.
- Bardolia C, Amin NS, Turgeon J. Emerging non-statin treatment options in lowering low-density lipoprotein cholesterol. Front Cardiovasc Med. 2021; doi.org/10.3389/fcvm.2021.789931.
- Bingham J, Michaud V, Wiisanen K, Bate J, Morreale A, Empey P, Crutchley R, Elnashar G, Gilbert J, Turgeon J. Improving patients’ outcomes through the integration of pharmacogenomic testing into comprehensive medication management care models. Journal of Precision Medicine. 2021 Sept;7(3):28-37.
- Bingham J, Stanislaw J, Warholak T, Scovis N, Axon R, Turgeon J, Marupuru S. Assessment of glycosylated hemoglobin outcomes following an Enhanced Medication Therapy Management Service via telehealth. Int J Environ Res Public Health. 2021;18(12):6560.
- Bingham J, Tranchina K, Turgeon J. Telepharmacy offers opportunity amid pandemic. Pharmacy Times. January 2021.
- Bull J, Bice T, Satterwhite W, Massie L, Burpee E, Knotkova H, Portenoy R. Contributors: Turgeon J, Michaud V, Matos A, Bankes D. Feasibility and acceptability of a pharmacogenomic decision support system in palliative care. J Pall Med. 2021. 10.1089/jpm.2021.0270. Epub ahead of print.
- Campbell PJ, Axon DR, Anderson EJ, Ekstrand M, Brumel A, Warholak T. Psychometric evaluation of a comprehensive medication management service experience instrument. JAPhA. EPub ahead of print. 2021.
- Campbell PJ, Axon DR, Taylor AM, Smith K, Pickering M, Black H, Warholak T, Chinthammit C. Hypertension, cholesterol and diabetes medication adherence, health care utilization and expenditure in a Medicare Supplemental sample. Medicine (Baltimore). 2021 Sep 3;100(35):e27143.
- Campbell P, Chinthammit C, Mollon L, Anderson S, Pickering M, Black H, Warholak T. Evaluating the relationship between quality measure adherence definitions and economic outcomes in commercial health plans: a retrospective diabetes cohort study. J Manag Care Spec Pharm. 2021 Jan;27(1):64-72.
- Chinthammit C, Bhattacharjee S, Lo-Ciganic WH, Axon DR, Slack M, Bentley JP, Warholak TL. Association of low-income subsidy, Medicaid dual eligibility, and disability status with high-risk medication use among Medicare Part D beneficiaries. Res Social Adm Pharm. 2021 May 11:S1551-7411(21)00171-6. doi: 10.1016/j.sapharm.2021.05.005. Epub ahead of print.
- Del Toro-Pagán NM, Matos A, Thacker D, Turgeon J, Amin NS, Michaud V. Pharmacist-led medication evaluation considering pharmacogenomics and drug-induced phenoconversion in the treatment of multiple comorbidities: A case report. Medicina. 2021; 57(9):955.
- Deodhar M, Rihani SBA, Darakjian L, Turgeon J, Michaud V. Assessing the mechanism of fluoxetine-mediated CYP2D6 inhibition. Pharmaceutics. 2021 Jan 23;13(2):148. doi: 10.3390/pharmaceutics13020148. PMID: 33498694.
- Deodhar, M.; Turgeon, J.; Michaud, V. Contribution of CYP2D6 functional activity to oxycodone efficacy in pain management: Genetic polymorphisms, phenoconversion, and tissue-selective metabolism. Pharmaceutics. 2021;13:1466.
- De Santiago A, Bingham JM, Vaffis S, Scovis N, McGlamery E, Boesen K, Warholak T, Dhatt H. Evaluating the role and value of a clinical pharmacist in a concierge primary care clinic. J Am Pharm Assoc (2003). 2021 Jan 18:S1544-3191(20)30635-X. doi: 10.1016/j.japh.2020.12.014. Epub ahead of print.
- Ha M, Amin N, Meyer K, Turgeon J, Bardolia C. Balancing sleep and motor symptoms: A Case report of managing insomnia in Parkinson’s Disease. Clin Case Rep 11. 2021: 1432.
- Ha M, Meyer K, Matos A, Turgeon J, Bardolia C. Optimizing medications in patients with cardiovascular disease: A case report on unrecognized prescribing cascades in older adults. Clin Case Rep J. 2021;2(3):1–5.
- Le L, Paulk I, Axon DR, Bingham JM. Comprehensive Medication Review completion in medically underserved areas and populations. Journal of Health Care for the Poor and Underserved. 2021;32(3):1301-11.
- Leal S. Be the voice. J Am Pharm Assoc. 2021;61(4)e8-9.
- Long T, Cristofoletti R, Cicali B, Michaud V, Dow P, Turgeon J, Schmidt S. Physiologically-based pharmacokinetic modeling to assess the impact of CYP2D6-mediated drug-drug interactions on tramadol and o-desmethyltramadol exposures via allosteric and competitive inhibition. Journal of Clinical Pharmacology. 2021 Aug 12. doi: 10.1002/jcph.1951. Epub ahead of print. PMID: 34383318.
- Lott BE, Anderson EJ, Villa Zapata L, Cooley J, Forbes S, Taylor AM, Manygoats T, Warholak T. Expanding pharmacists’ roles: Pharmacists’ perspectives on barriers and facilitators to collaborative practice. J Am Pharm Assoc (2003). 2020 Dec 24:S1544-3191(20)30624-5. doi: 10.1016/j.japh.2020.11.024. Epub ahead of print.
- Matos A, Dow P, Bingham J, Michaud V, Lesko L, Knowlton C, Turgeon J. Tabula Rasa HealthCare company profile: Involvement on pharmacogenomic and personalized medicine research. Pharmacogenomics. 2021 [Epub ahead of print] DOI: 10.2217/pgs-2021-0085.
- Michaud V, Smith M, Bikmetov R, Dow P, Johnson J, Stein A, Finnel S, Jin H, Turgeon J. Association of the MedWise Risk Score with health care outcomes. Am J Manag Care. 2021;27(suppl 16):S280-S291.
- Michaud V, Bikmetov R, Smith MK, Dow P, Darakjian LI, Deodhar M, Cicali B, Bain KT, Turgeon J. Use of drug claims data and a medication risk score to assess the impact of CYP2D6 drug interactions among opioid users on healthcare costs. J. Pers. Med. 2021, 11, 1174.
- Michaud V, Turgeon J. Precision medicine: Applied concepts of pharmacogenomics in patients with various diseases and polypharmacy. Pharmaceutics. 2021;13(2):197.
- Moghadam S, Leal S. How should physicians and pharmacists collaborate to motivate health equity in underserved communities? AMA J Ethics. 2021;23(2):E117-126. doi: 10.1001/amajethics.2021.117.
- Pizzolato K, Meyer K, Matos A, Turgeon J, Bardolia C. Pharmacist-led medication review identifies and mitigates fall-risk-increasing drugs and multi-drug interactions. Clin Case Rep. 2021: 11(7).
- Pizzolato, K.; Thacker, D.; Toro-Pagán, N.D.; Hanna, A.; Turgeon, J.; Matos, A.; Amin, N.; Michaud, V. Cannabis dopaminergic effects induce hallucinations in a patient with Parkinson’s Disease. Medicina 2021, 57, 1107.
Ratigan A, Michaud V, Turgeon J, Bikmetov R, Gaona G, Anderson H, Pulver G, Pace W. Longitudinal association of a medication risk score with mortality among ambulatory patients acquired through electronic health record data. Journal of Patient Safety. 2021 March 24. doi: 10.1097/PTS.0000000000000829 EPub ahead of print.
Rihani S, Darakjian L, Deodhar M, Dow P, Turgeon J, Michaud V. Disease-induced modulation of drug transporters at the blood–brain barrier level. Int J Mol Sci. 2021, 22(7), 3742.
- San Filippo S, Michaud V, Wei J, Bikmetov R, Turgeon J, Brunetti L. Classification and assessment of medication risk in the elderly (CARE): Use of a medication risk score to inform patients’ readmission likelihood after hospital discharge. Journal of Clinical Medicine. 2021, 10, 3947.
- Silva-Almodóvar A, Hackim E, Wolk H, Nahata MC. Potentially inappropriately prescribed medications among Medicare Medication Therapy Management eligible patients with chronic kidney disease: An observational analysis. J Gen Intern Med. 2021 Jan 27. doi: 10.1007/s11606-020-06537-z. Epub ahead of print.
- Smith MK, Bikmetov R, Al Rihani SB, Deodhar M, Hafermann M, Dow P, Turgeon J, Michaud V. Adverse drug event risk assessment by the virtual addition of COVID-19 repurposed drugs to Medicare and commercially insured patients’ drug regimens: A drug safety simulation study. Clin Transl Sci. 2021 Mar 30. doi: 10.1111/cts.13025. Epub ahead of print. PMID: 33786990.
- Stein A, Finnel S, Bankes D, Jin H, Awadalla M, Johnson J, Turgeon J. Health outcomes from an innovative Enhanced Medication Therapy Management model. Am J Manag Care. 2021;27(suppl 16):S300-S308.
- Tranchina K, Turgeon J, Bingham J. Integrating a novel medication risk score and use of an advanced clinical decision support system into a pharmacist and nurse-coordinated transition of care program to mitigate drug interactions. Clin Case Rep J. 2021;2(1):1–5.
- Wani A, Al Rihani SB, Sharma A, Weadick B, Govindarajan R, Khan SU, Sharma PR, Dogra A, Nandi U, Reddy CN, Bharate SS, Singh G, Bharate SB, Vishwakarma RA, Kaddoumi A, Kumar A. Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway. Autophagy. 2021 Jan 19:1-20.
- Axon DR, Slack M, Warholak T. Identifying predictors of opioid use among older United States adults with pain. J Opioid Manag.
- Communication and use of telehealth in the context of disasters and emergency preparedness (book chapter).
- Grangeon A, Clermont V, Barama A, Gaudette F, Turgeon T, Michaud V. Determination of CYP450 expression levels in the human small intestine by mass spectrometry-based targeted proteomics. Int J Med Sci.
- Michaud M, Darakjian L, Dow P, Turgeon J. Role of pharmacogenomics in reducing the risk of drug-related iatrogenesis. PHAR Current Pharmacology Reports. PHAR Current Pharmacology Reports.
- Michaud V, Dow P, Turgeon J. Illustrative and historic cases of phenoconversion. Am J Translational Research.
- Michaud M, Dow P, Turgeon J. Letter to the Editor: “Empiric segmentation of high-risk patients: A structured literature review.” American Journal of Managed Care.
- Sreeram A, Matos A, Amin NS, Meyer K, Turgeon J, Bardolia C. Pharmacist’s role in deprescribing medications in an adult with end-stage kidney disease. Clin Case Rep.
- Almodovar AS, Malfara A, Nahata M. Impact of automated targeted medication review electronic alerts to reduce potentially inappropriate medication prescribing among Medicare enrolled patients with dementia. Ann Pharmacother. 2020 Apr 22;54(10):967-974. DOI: 1060028020915790.
- Almodovar AS, Nahata M. Potentially harmful medication use among Medicare patients with heart failure. Am J Cardiovasc Drugs. 2020;20(6):603-610.
- Al Rihani S, Deodhar M, Dow P, Turgeon J, Michaud V. Is dexamethasone a substrate, an inducer, or a substrate-inducer of CYP3As? Archives of Pharmacy & Pharmacology Research. 2020;2(5):1-5.
- Anderson EA, Axon DR, Taylor AM, Towers V, Warholak T, Johnson M, Forbes S, Manygoats T. Impact evaluation of a four-year academic-community partnership in provision of medication management and tertiary prevention services for rural patients with diabetes and/or hypertension. Preventive Medicine Reports. 2020 Mar 17. 101038.
- Anderson E, Lott B, Zapata L, Cooley J, Forbes S, Taylor A, Warholak T. Pharmacists’ perceptions of the pharmacists’ patient care process and performance in a simulated patient interaction. J Am Pharm Assoc. 2020 Apr 27;60(6):796-803. [Epub ahead of print].
- Axon D, Chinthammit C, Taylor AM, Tate J, Leal S, Pickering M, Black H, Warholak T, Campbell P. Prevalence of current procedural terminology (CPT) codes for medication therapy management
(MTM) services in administrative claims data. Value in Health. 2020;23(Supplement 1 ): S305. - Axon R, Tate J, Campbell P, Taylor A, Pickering M, Black H, Leal S, Warholak T, Chinthammit C. Current procedural terminology codes for medication therapy management in administrative data. J Manag Care Spec Pharm. 2020 Oct;26(10):1297-1300.
- Bain KT, Knowlton CH, Matos A. Cost avoidance related to a pharmacist-led pharmacogenomics service for the Program of All-inclusive Care for the Elderly. Pharmacogenomics. 2020 Jul;21(10):651-661.
- Ballinghoff T, Bain KT, Matos A, Bardolia C, Turgeon J, Amin NS. Opioid response in an individual with altered cytochrome P450 2D6 activity: implications of a pharmacogenomics case. Clin Case Rep J. 2020 Nov 10;1(6):1-4.
- Bankes DL, Amin NS, Bardolia C, Awadalla MS, Knowlton CH, Bain KT. Medication-related problems encountered in the Program of All-inclusive Care for the Elderly: An observational study. J Am Pharm Assoc (2003). 2020 Mar-Apr;60(2):319-327.
- Bankes D, Jin H, Finnel S, Michaud V, Knowlton C, Turgeon J, Stein A. Association of a novel medication risk score with adverse drug events and other pertinent outcomes among participants of the Programs of All-Inclusive Care for the Elderly. Pharmacy. 2020 May 20;8(2):87.
- Bankes D, Schamp R, Knowlton C, Bain K. Prescriber initiated engagement of pharmacists for information and intervention in Programs of All-inclusive Care for the Elderly. Pharmacy. 2020 Feb 21;8(1):24.
- Bingham J, Almodovar A, Lee H, Benson C, Michael R, Azurin C, Taylor A. The role of the pharmacist in mental health: An investigation of the impact of a pharmacist-led interventions on psychotropic medication adherence in patients with diabetes. J Am Pharm Assoc (2003). 2020 Feb 26;60(4):e58-e63. pii: S1544-3191(20)30014-5.
- Bingham J, Almodovar A, Taylor A, Axon D, Nahata M, Leal S, Warholak T, Scovis N. A research partnership to enhance postgraduate pharmacy training outcomes. Pharmacy. 2020 Jul 31;8(3):134.
- Bingham J, Axon DR, Boesen K, Taylor A. Preliminary investigation of pharmacist-delivered, direct-to provider interventions to reduce co-prescribing of opioids and benzodiazepines among a Medicare population. Pharmacy. 2020 Feb 21;8(1 ):25.
- Bingham J, Black M, Anderson E, Li Y, Toselli N, Fox S, Martin J, Axon D, Silva-Almodovar. Impact of telehealth interventions on medication adherence for patients with type 2 diabetes, hypertension, dyslipidemia: A systematic review. Ann Pharmacother. 2020 Aug 20;55(5):637-649. [EPub ahead of print].
- Bingham J, De Santiago A, Everett W, Stanislaw J. A practical approach to remote precepting in a chronic disease management call center setting during a pandemic. Am J Health Syst Pharm. 2020 Nov 27;78(4):298-291. DOI: 10.1093/ajhp/zxaa370.
- Bingham J, Michaud V, Turgeon J, Axon D. Effectiveness of an advanced clinical decision support system on clinical decision-making skills in a call center medication therapy management pharmacy setting: A pilot study. Pharmacy. 2020 Nov 25;8(4):228.
- Chinthammit C, Axon DR, Anderson S, Lott B, Taylor AM, Pickering M, Black H, Warholak T, Campbell PJ. A retrospective cohort study evaluating the relationship between statin medication adherence and economic outcomes in commercial health plans. J Clin Lipidol. 2020 Nov 1;14(6):791-798.
- Deodhar M, Al Rihani S, Arwood M, Darakjian L, Dow P, Turgeon J, Michaud V. Mechanisms of CYP450 inhibition: Understanding drug-drug interactions due to mechanism-based inhibition in clinical practice. Pharmaceutics. 2020 Sep 4;12(9):846.
- Deodhar M, Dow P, Al Rihani SB, Turgeon J, Michaud V. An illustrative case of phenoconversion due to multi-drug interactions. Clin Case Rep. 2020 May 13;1(3):1-6.
- Dhatt H, Marupuru S, Warholak TL. A motivational factors assessment instrument for medication management center employees providing medication therapy management services: A Rasch analysis. J Am Pharm Assoc (2003). 2020 Sep 24;61(1):34-43. DOI: 10.1016/j.japh.2020.08.040. [Epub ahead of print].
- Furman A, Bardolia C, Meyer K, Turgeon J, Amin N. Identifying adverse drug effects of amiodarone through a pharmacist-led comprehensive review. Clin Case Reports. 2020 Jul 7;10(8).
- Gabbay R, Kendall D, Beebe C, Cuddeback J, Hobbs T, Khan N, Leal S, Miller E, Novak L, Rajpathak S, Scribner P, Meneghini L, Khunti K. Addressing therapeutic inertia in 2020 and beyond: A 3-year initiative of the American Diabetes Association. Clinical Diabetes. 2020 Oct;38(4):371-381. DOI: 10.2337/cd20-0053.
- Galiano L, Hingle N, Kurlin K, Michaud V, Dow P, Turgeon J. Mechanisms and clinical relevance of drug-induced Long QT Syndrome: Block of hERG, drug metabolism and drug transport in the human heart. Ann Pharmacol Pharmaceut. 2020 Jan 7;5(2):1176.
- Guerra B, Vaffis S, Axon DR, Leal S, Warholak T, Taylor AM, Scovis N. Perceptions and experiences of promotoras and pharmacists in an academic-community partnership providing telephonic MTM services to a Spanish-speaking, rural population: A focus group study. J Manag Care Spec Pharm. 2020 Nov;26(11):1390-1397.
- Hall-Lipsy E, Anderson EJ, Taylor AM, Warholak T, Axon DR, Faqeeri Z, Jastrzab R. Community health worker perspectives of an academic community medication therapy management collaboration. J Amer Pharm Assoc. (2003). 2020 Jan 6;60(3):475-480.
- Jamjoom O, Marupuru S, Scovis N, Warholak T, Taylor A, Bingham J. Evaluating provider acceptance of pharmacist interventions in the Discharge Companion Program and its impact on readmission reduction. J Am Pharm Assoc (2003). 2020 Feb 6;60(4):e47-e51.
- Kassem I, Sanche S, Li J, Bonnefois G, Dube M, Rouleau J, Tardif J, White M, Turgeon J, Nekka F, Denus S. Population pharmacokinetics of candesartan in patients with chronic heart failure. Clin Transl Sci. 2020 Aug 28;14(1):194-203.
- Leal S (contributing author). Environmental scan of pharmacogenomics in health care HIT infrastructure. Pharmacy Health Information Technology Collaborative. 2020 Dec 16.
- Lott BE, Anderson EJ, Villa lapata L, Cooley J, Forbes S, Taylor AM, Manygoats T, Warholak T. Expanding pharmacists’ roles: Pharmacists’ perspectives on barriers and facilitators to collaborative practice. J Am Pharm Assoc (2003). 2020 Dec 24. DOI: 10.1016/j.japh.2020.11.024. [Epub ahead of print].
- Marupuru S, Axon DR, Campbell P, Chinthammit C, Forbes S, Martin R, Taylor A, Warholak T. Exploring performance predictors among employees in a pharmacist-led medication management center. J Amer Pharm Assoc. 2020. [Epub ahead of print].
- Matos A, Bain KT, Bankes DL, Furman A, Skalski B, Verzicco J, Turgeon. Cytochrome P450 (CYP450) interactions involving atypical antipsychotics are common in community-dwelling older adults treated for behavioral and psychological symptoms of dementia. Pharmacy (Basel). 2020 Apr 8;8(2): E63.
- Matos A, Bankes D, Bain K, Ballinghoff T, Turgeon J. Opioids, polypharmacy, and drug interactions: A technological paradigm shift is needed to ameliorate the ongoing opioid epidemic. Pharmacy. 2020 Aug 25;8(3):154.
- Michaud V, Deodhar M. Arwood M, Al Rihani S, Dow P, Turgeon K. ACE2 as a therapeutic target for COVID-19; Its role in infectious processes and regulation by modulators of the RAAS system. J Clin Med. 2020 Jul 3;9(7):2096.
- Michaud V, Dow P, Al Rihani S, Deodhar M, Arwood M, Cicali B, Turgeon J. Risk assessment of drug-induced Long QT Syndrome for some COVID-19 repurposed drugs. Clin Transl Sci. 2020 [EPub ahead of print].
- Sachdev G, Kliethermes M, Vernon V, Leal S, Crabtree G. Current status of prescriptive authority by pharmacists in the United States. J Am Coll Clin Pharm. 2020 Apr 26;3(4). DOI:10.1002/jac5.1245.
- Shoojat S, Bardolia C, Turgeon J, Amin N. Medication-related problems in older adults and the importance of comprehensive medication. Clin Case Reports. 2020.10(8).
- Sid-Otmane L, Hamadjida A, Nuara S, Bedard D, Gaudette F, Gourdon J, Michaud V, Beaudry F, Panisset M, Huot P. Selective metabotropic glutamate receptor 2 positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviors and dyskinesia in the MPTP-lesioned marmoset. Eur J Pharmacol. 2020 Apr 15;873:172957.
- Silva-Almodovar A, Smith K, Nahata MC. Relationship between patient characteristics and number of phone calls to complete a telehealth comprehensive medication review: A cross-sectional analysis. J Am Pharm Assoc (2003). 2020 Jul 18;60(6):923-929. DOI: 10.1016/j.japh.2020.06.019. [Epub ahead of print].
- Turgeon J, Michaud V. Medication monitor: Decreasing adverse drug events. Today’s Geriatric Medicine. 2020. 13( 1 ):8.
- Wright SA, Bardolia C, Bankes D, Amin N, Turgeon J. Angiotensin converting enzyme (ACE) inhibitor-induced cough resulting in prescribing cascade. Clin Case Rep. 2020;10(7).
